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KNTC1 introduces segmental heterogeneity to mitochondria.
- Source :
-
Disease models & mechanisms [Dis Model Mech] 2025 Jan 20. Date of Electronic Publication: 2025 Jan 20. - Publication Year :
- 2025
- Publisher :
- Ahead of Print
-
Abstract
- Mitochondria contribute to cellular metabolism by providing a specialised milieu for energising cells by incorporating and processing the metabolites. However, heterogeneity in the mitochondria within is only partially elucidated. Mitochondria dynamically alter their morphology and functions during the life of animals, in which cells proliferate and grow. We here show that Kntc1, a highly evolutionarily conserved protein, translocates from the Golgi apparatus to linear mitochondrial segments (LMS) upon glutamine deprivation and plays an essential role in maintaining LMS. The LMS with Kntc1 localisation exhibits an increase in the membrane potential, suggesting the role of Kntc1 in functioning as a reservoir for the energy-generating potential. Suppression of Kntc1 leads to glutamine consumption and lactate production, thus impacting cellular metabolism, eventually leading to anchorage-independent growth of cells. Indeed, the KNTC1 variant was identified in a patient with ovarian cancer, suggesting that segmental regulation of the mitochondrial function is essential for maintaining tissue integrity.<br /> (© 2025. Published by The Company of Biologists.)
Details
- Language :
- English
- ISSN :
- 1754-8411
- Database :
- MEDLINE
- Journal :
- Disease models & mechanisms
- Publication Type :
- Academic Journal
- Accession number :
- 39829138
- Full Text :
- https://doi.org/10.1242/dmm.052063