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Acute physical exercise and ambulatory blood pressure in resistant hypertension.

Authors :
Saco-Ledo G
Valenzuela PL
Almazán-Polo J
Plaza-Florido A
Alejo LB
Bustos A
Río-García A
Gálvez BG
Rubio-González E
Fiuza-Luces C
León-Sanz M
Boraita A
Santos-Lozano A
Ruilope LM
Lucia A
Source :
Journal of hypertension [J Hypertens] 2025 Mar 01; Vol. 43 (3), pp. 445-455. Date of Electronic Publication: 2024 Nov 11.
Publication Year :
2025

Abstract

Objectives: The effects of acute physical exercise in patients with resistant hypertension remain largely unexplored compared with hypertensive patients in general. We assessed the short-term effects of acute moderate-intensity (MICE) and high-intensity interval exercise (HIIE) on the clinic (BP) and 24-h ambulatory blood pressure (ABP) of patients with resistant hypertension.<br />Methods: Using a crossover randomized controlled design, 10 participants (56 ± 7 years) with resistant hypertension performed three experimental sessions: MICE, HIIE, and control. MICE consisted of continuous treadmill exercise at an intensity of 3-4 metabolic equivalents of energy (METs) until completing 3 kcal/kg and was energy-matched to HIIE (which included six to eight intervals of 3 min duration at 6-7 METs interspersed with 1.5-min rests at 3 METs). In the control session, participants remained seated for 50 min. Flow-mediated vasodilation, autonomic nervous system balance (heart rate variability), exerkines [interleukin (IL)-6, IL-8, IL-15, vascular endothelial growth factor A, irisin, adiponectin, and angiopoietin] and 71 inflammatory-related proteins were also measured.<br />Results: Compared with baseline, HIIE and MICE reduced clinic SBP immediately ( P  < 0.001 for both) and 90 min ( P  = 0.001 and P  = 0.041, respectively) postexercise. HIIE and MICE also reduced clinic DBP immediately postexercise ( P  = 0.003 and P  = 0.025). By contrast, no changes were found in the control session. On the other hand, no significant effects were noted for 24 h ABP measures or for the rest of variables.<br />Conclusion: Although in patients with resistant hypertension, acute aerobic exercise induces short-term reductions in clinic BP, this stimulus does not suffice to reduce 24 h ABP or to impact on potential biological mechanisms.<br /> (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Details

Language :
English
ISSN :
1473-5598
Volume :
43
Issue :
3
Database :
MEDLINE
Journal :
Journal of hypertension
Publication Type :
Academic Journal
Accession number :
39823644
Full Text :
https://doi.org/10.1097/HJH.0000000000003924