Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content.

Authors :: Torrisi J
Chvojka M
Jurček P
Zhang X
Zeng H
Šindelář V
Valkenier H
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Jan 10, pp. e202424754. Date of Electronic Publication: 2025 Jan 10.
Publication Year :: 2025
Publisher :: Ahead of Print
Abstract: Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.<br /> (© 2025 The Author(s). Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

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