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Liver affection in iron overload studied with serum ferritin and serum aminotransferases.
- Source :
-
Acta medica Scandinavica [Acta Med Scand] 1985; Vol. 217 (1), pp. 79-84. - Publication Year :
- 1985
-
Abstract
- Liver dysfunction as measured by S-ALAT activity was present in 72% of patients over 40 years of age with HLA-related iron overload, mainly detected by laboratory screening. Liver dysfunction was correlated to the amount of iron stored (r = 0.54, p less than 0.001). When iron was removed by phlebotomy, liver function returned to normal. S-ALAT activity was closely correlated to serum ferritin concentration (r = 0.73, p less than 0.001). Even a mild iron excess can affect hepatocytes and result in increased levels of ferritin and aminotransferases in serum. Patients with "transaminitis" should be investigated for iron overload.
Details
- Language :
- English
- ISSN :
- 0001-6101
- Volume :
- 217
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta medica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 3976436
- Full Text :
- https://doi.org/10.1111/j.0954-6820.1985.tb01638.x