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Immunogenicity of Short-Course, High-Dose Hepatitis B Vaccination in Patients with Chronic Kidney Disease - Shanxi Province, China, 2019-2020.

Immunogenicity of Short-Course, High-Dose Hepatitis B Vaccination in Patients with Chronic Kidney Disease - Shanxi Province, China, 2019-2020.

Authors :
Gao L
Cui X
Mo X
Men Z
Xu X
Yao T
Wang J
Liu H
Guo H
Chai G
Liu L
Wang F
Liang X
Wang S
Feng Y
Source :
China CDC weekly [China CDC Wkly] 2024 Dec 13; Vol. 6 (50), pp. 1331-1336.
Publication Year :
2024

Abstract

What Is Already Known About This Topic?: As one of the populations at high risk of hepatitis B virus (HBV) infection, patients with chronic kidney disease (CKD) require rapid and effective development of hepatitis B surface antibodies (anti-HBs).<br />What Is Added by This Report?: The short-course, high-dose regimen of hepatitis B vaccination rapidly induced comparable immunological responses to the routine regimen, achieving a seroconversion rate of 88.5%, a high-response rate of 64.1%, and anti-HBs geometric mean concentrations of 824.1 mIU/mL.<br />What Are the Implications for Public Health Practice?: The short-course, high-dose regimen represents an effective rapid immunization strategy for CKD patients, particularly when administered prior to immunosuppressive therapy. This study provides compelling evidence for optimizing immunization protocols in the CKD population.<br />Competing Interests: The authors declare that there is no potential conflict of interest.<br /> (Copyright © 2024 by Chinese Center for Disease Control and Prevention.)

Details

Language :
English
ISSN :
2096-7071
Volume :
6
Issue :
50
Database :
MEDLINE
Journal :
China CDC weekly
Publication Type :
Academic Journal
Accession number :
39734783
Full Text :
https://doi.org/10.46234/ccdcw2024.264