MXene as SERS-Active Substrate: Impact of Intrinsic Properties and Performance Analysis.

A new member is incorporated into the SERS active materials family daily as a consequence of advances in materials science. Furthermore, it has been demonstrated that MXenes, which display remarkable physicochemical characteristics, are also encompassed within this family. This Review offers a comprehensive and systematic assessment of the potential of MXene structures in the context of SERS applications. First, the historical development of SERS-active substrates and the evolution of various substrates over time are analyzed. Subsequently, the formation and structural properties of MXene structures were subjected to a comprehensive and detailed examination. The principal objective of this Review is to elucidate the rationale behind the preference for MXene as a SERS-active substrate, given its distinctive physicochemical properties. In this context, while MXene's abundant surface functional groups represent a significant advantage, its high electrical conductivity, suitable flexibility, extensive two-dimensional surface areas, and antibacterial activity also warrant consideration in terms of potential applications. It is emphasized that, for MXene nanolayers to demonstrate optimal performance in SERS applications, a plan should be devised to consider these features. By increasing readers' awareness of using MXene as a SERS active substrate, potential opportunities for future application areas may be created.