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Fanlian Huazhuo Formula: A promising herbal preparation for metabolic liver disease.
Fanlian Huazhuo Formula: A promising herbal preparation for metabolic liver disease.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2024 Dec 14; Vol. 30 (46), pp. 4964-4968. - Publication Year :
- 2024
-
Abstract
- The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has increased significantly in recent decades and is projected to increase further due to the rising obesity rates. MASLD patients are at higher risk of developing advanced liver diseases "cirrhosis and hepatocellular carcinoma" as well as liver- or cardiovascular-related mortality. Existing lipid-lowering therapies failed to reduce the risk of mortality in these patients. Therefore, there is an urgent need for pharmacotherapies that can control and even reverse this disease. Fanlian Huazhuo Formula (FLHZF) is a combination herbal preparation, and its various individual constituents regulate hepatic lipid metabolism, adipose tissue inflammation, and gut microbiota. Despite, these useful effects, limited information is available on its benefits in diet-induced hepatosteatosis. In this article, we discuss the research findings recently published about the therapeutic effects of FLHZF in suppressing MASLD development and underlying mechanisms. Utilizing a series of in vitro and in vivo experiments, the authors demonstrated for the first time that FLHZF suppresses MASLD in male mice possibly by inhibiting hepatic de novo lipogenesis pathways and reducing hepatocyte death. This study paves the way for future investigations aimed at investigating FLHZF's role in inhibiting lipogenesis particularly using radioactively-labeled glucose and acetate, and governing hepatocyte mitochondrial function, gut microbiome profile, and its effects in other models of MASLD, and female mice.<br />Competing Interests: Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.<br /> (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Subjects :
- Animals
Humans
Mice
Male
Lipogenesis drug effects
Disease Models, Animal
Hepatocytes drug effects
Hepatocytes metabolism
Non-alcoholic Fatty Liver Disease drug therapy
Non-alcoholic Fatty Liver Disease metabolism
Fatty Liver drug therapy
Fatty Liver metabolism
Phytotherapy methods
Drugs, Chinese Herbal therapeutic use
Drugs, Chinese Herbal pharmacology
Liver drug effects
Liver metabolism
Liver pathology
Gastrointestinal Microbiome drug effects
Lipid Metabolism drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 30
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 39679304
- Full Text :
- https://doi.org/10.3748/wjg.v30.i46.4964