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Combined preoperative and postoperative radiation for bladder cancer. Results of RTOG/Jefferson Study.
- Source :
-
Cancer [Cancer] 1985 Mar 01; Vol. 55 (5), pp. 963-6. - Publication Year :
- 1985
-
Abstract
- Ninety-two patients with bladder cancer have been treated with combined pre- and postoperative radiation in a Radiation Oncology Study Group (RTOG) Phase I-II study and at Thomas Jefferson University Hospital. Patients with invasive bladder cancer were entered into the study and given low-dose preoperative radiation (500 rad) to the whole pelvis, either on the day of or the day before cystectomy. Following surgery, patients were pathologically staged. Patients with stage B1 (T2) (grade 3 or 4), stage B2 and C (T3) tumors were given 4500 rad in 5 weeks postoperative radiation. Follow-up in the study ranges from a minimum of 24 months to 5 years, with a median of 36 months. Incidence of complications was 15% (14/92). The 4-year actuarial survival (Kaplan-Meier) by stage of disease is 68% for stage B1 (T2) (grade 3 or 4), 78% for stage B2, and 57% for stage C. These survival results appear to be better than those obtained with other approaches of adjuvant therapy and/or surgery in comparable histopathologically staged patients.
- Subjects :
- Carcinoma, Transitional Cell mortality
Carcinoma, Transitional Cell surgery
Humans
Neoplasm Staging
Postoperative Complications
Radiotherapy adverse effects
Urinary Bladder Neoplasms mortality
Urinary Bladder Neoplasms pathology
Urinary Bladder Neoplasms surgery
Carcinoma, Transitional Cell radiotherapy
Postoperative Care
Preoperative Care
Urinary Bladder Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 55
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 3967204
- Full Text :
- https://doi.org/10.1002/1097-0142(19850301)55:5<963::aid-cncr2820550508>3.0.co;2-#