Analysis of twelve human milk oligosaccharides over fifteen months post-partum in human milk from Chinese mothers.

Human milk Oligosaccharides (HMOs) are a major component in human milk and recognized to play an important role in modulating gut microbiota, intestinal cell response, and the development of the brain and immune system. While HMOs levels from Chinese mothers across different regions of China have been reported, data from Hebei are lacking. Twelve HMOs were measured from a cross-section of Hebei Han mothers over a 15-month lactation period. The average total of the 12 measured HMOs was 4872 ± 1902 mg/L, similar to that reported for Han mothers from other Chinese regions. Hebei Han mothers had much lower LNnT (59.0 ± 53.1 mg/L), LNFP II (257.5 ± 211.0 mg/L) and LNFP III (149.9 ± 121.7 mg/L) levels and higher 3FL levels (1875.2 ± 1065.3 mg/L) compared to other regional Chinese mother cohorts. The distribution of secretor and Lewis status for this Hebei mother cohort was measured at 68.5 %, 21.9 %, 8.2 % and 1.4 % respectively for Se ⁺ Le ⁺ , Se ^- Le ⁺ , Se ⁺ Le ^- and Se ^- Le ^- respectively. The results from this study suggest that location has influence over the HMOs concentration.
Competing Interests: The authors declare they have no conflict of interest. Yibing Ning, Yiping Xun, Huanzhe Dong and Qingbin Yuan are employees of Junlebao Dairy Groups Co. Ltd, China, while Bertram Fong, Paul McJarrow and Lin Ma are employees of Fonterra Dairy Group Ltd, New Zealand. Dr Hamid Jan Jan Mohamed is Professor at the School of Health Sciences, Universiti Sains Malaysia, Malaysia.
(© 2024 The Authors.)