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Minoxidil, nadolol, and a diuretic. Once-a-day therapy for resistant hypertension.
- Source :
-
Archives of internal medicine [Arch Intern Med] 1986 May; Vol. 146 (5), pp. 882-6. - Publication Year :
- 1986
-
Abstract
- We tested a once-a-day antihypertensive regimen using minoxidil, nadolol, and a diuretic in 55 patients with resistant hypertension. Forty-seven patients had evidence of end-organ damage. Twelve had mild renal insufficiency (serum creatinine concentration, 2.5 +/- 0.3 mg/dL). In 34 patients, treatment with nadolol and a diuretic was started with minoxidil added one to four weeks later. In the remainder, minoxidil, nadolol, and a diuretic were begun simultaneously because of severe hypertension. Initial supine and standing blood pressure (BP) in the 55 patients were 186 +/- 4/111 +/- 2 and 180 +/- 4/108 +/- 2 mm Hg, respectively. After 7 +/- 1 weeks, BP was controlled in 46 patients (84%) with the supine and standing BP reduced to 140 +/- 3/80 +/- 1 and 134 +/- 3/80 +/- 1, respectively. In six patients, BP was controlled but intolerable side effects occurred, making the regimen therapeutically successful in 40 patients (73%). The BP remained controlled during a follow-up of 43 +/- 5 weeks. In 31 patients, BPs measured 24 hours after the last dose were not different from random measurements. Mean serum creatinine levels remained stable in the 12 patients with renal insufficiency.
- Subjects :
- Adult
Aged
Blood Pressure drug effects
Creatinine blood
Diuretics therapeutic use
Drug Administration Schedule
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Hypertension physiopathology
Male
Middle Aged
Minoxidil therapeutic use
Nadolol
Posture
Propanolamines therapeutic use
Diuretics administration & dosage
Hypertension drug therapy
Minoxidil administration & dosage
Propanolamines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9926
- Volume :
- 146
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 3963979