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The tigecycline resistance mechanisms in Gram-negative bacilli.

Authors :
Wang Z
Li H
Source :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Nov 20; Vol. 14, pp. 1471469. Date of Electronic Publication: 2024 Nov 20 (Print Publication: 2024).
Publication Year :
2024

Abstract

Tigecycline, hailed as a pivotal agent in combating multidrug-resistant bacterial infections, confronts obstacles posed by the emergence of resistance mechanisms in Gram-negative bacilli. This study explores the complex mechanisms of tigecycline resistance in Gram-negative bacilli, with a particular focus on the role of efflux pumps and drug modification in resistance. By summarizing these mechanisms, our objective is to provide a comprehensive understanding of tigecycline resistance in Gram-negative bacilli, thereby illuminating the evolving landscape of antimicrobial resistance. This review contributes to the elucidation of current existing tigecycline resistance mechanisms and provides insights into the development of effective strategies to manage the control of antimicrobial resistance in the clinical setting, as well as potential new targets for the treatment of tigecycline-resistant bacterial infections.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Wang and Li.)

Details

Language :
English
ISSN :
2235-2988
Volume :
14
Database :
MEDLINE
Journal :
Frontiers in cellular and infection microbiology
Publication Type :
Academic Journal
Accession number :
39635040
Full Text :
https://doi.org/10.3389/fcimb.2024.1471469