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Ferlapioside: a new bromine substituted iridoid glycoside from the roots of Ferula lapidosa Korovin.
- Source :
-
Natural product research [Nat Prod Res] 2024 Dec 01, pp. 1-8. Date of Electronic Publication: 2024 Dec 01. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- One new bromine substituted iridoid glycoside, ferlapioside ( 1 ), was isolated from the roots of Ferula lapidosa Korovin, together with 10 known ones including seven iridoid glycosides ( 2 - 8 ) and three sesquiterpene lactones ( 9 - 11 ). Their structures were elucidated by extensive spectroscopic analyses, e.g. 1D and 2D-NMR, HR-ESI-MS, IR, UV, CD techniques, and comparison with literature values. Compounds 1 and 3 - 11 were evaluated for inhibitory activity against LPS-induced NO production in the RAW 264.7 cells and the in vitro cytotoxic activity against five human cancer cell lines (HL-60, A549, SMMC-7721, MDA-MB-231 and SW480). However, none of them exhibit significant anti-inflammatory and cytotoxic activity. This study will provide a scientific basis and reference for the further development and utilisation of Ferula plants.
Details
- Language :
- English
- ISSN :
- 1478-6427
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 39618161
- Full Text :
- https://doi.org/10.1080/14786419.2024.2432613