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Ni-Catalyzed Stereodivergent Synthesis of N-Glycosides.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Nov 29, pp. e202403822. Date of Electronic Publication: 2024 Nov 29. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Herein, we describe a stereoselective Ni-catalyzed N-glycosylation of glycals. The reaction is enabled by addition of an in situ generated nickel hydride across an olefin prior to C-N bond-formation. Stereodivergence can be accomplished on kinetic or thermodynamic grounds, thus giving access to either α- or β-N-glycosides with equal ease. The protocol is distinguished by its operational simplicity, generality and exquisite selectivity, thus offering a new gateway to expedite the synthesis of N-glycosides.<br /> (© 2024 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 39612346
- Full Text :
- https://doi.org/10.1002/chem.202403822