Current gaps in acute reperfusion therapies.

Purpose of Review: Advances in intravenous thrombolysis and endovascular thrombectomy have significantly reduced disability and improved outcomes associated with acute ischemic stroke.
Recent Findings: An expansion of indications for reperfusion therapies in select groups of patients to permit treatment in an extended time window, with large ischemic core, and with simplified imaging protocols have enabled a broader group of patients access to disability-sparing therapy. Cerebroprotection has had renewed development in the era of acute reperfusion.
Summary: In this review, we highlight recent developments in stroke reperfusion research and related questions that are under study or remain unanswered.
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