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Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review.
- Source :
-
Biomolecules [Biomolecules] 2024 Nov 14; Vol. 14 (11). Date of Electronic Publication: 2024 Nov 14. - Publication Year :
- 2024
-
Abstract
- Despite the significant progress in diagnostic and therapeutic strategies, vascular diseases, such as cardiovascular diseases (CVDs) and respiratory diseases, still cannot be successfully eliminated. Vascular cells play a key role in maintaining vascular homeostasis. Notably, a variety of cells produce and secrete platelet-derived growth factors (PDGFs), which promote mitosis and induce the division, proliferation, and migration of vascular cells including vascular smooth muscle cells (SMCs), aortic SMCs, endothelial cells, and airway SMCs. Therefore, PDGF/PDGR receptor signaling pathways play vital roles in regulating the homeostasis of blood vessels and the onset and development of CVDs, such as atherosclerosis, and respiratory diseases including asthma and pulmonary arterial hypertension. Recently, accumulating evidence has demonstrated that microRNA, long-chain non-coding RNA, and circular RNA are involved in the regulation of PDGF/PDGFR signaling pathways through competitive interactions with target mRNAs, contributing to the occurrence and development of the above-mentioned diseases. These novel findings are useful for laboratory research and clinical studies. The aim of this article is to conclude the recent progresses in this field, particular the mechanisms of action of these non-coding RNAs in regulating vascular remodeling, providing potential strategies for the diagnosis, prevention, and treatment of vascular-dysfunction-related diseases, particularly CVDs and respiratory diseases.
- Subjects :
- Humans
Animals
Muscle, Smooth, Vascular metabolism
MicroRNAs genetics
MicroRNAs metabolism
RNA, Long Noncoding genetics
RNA, Long Noncoding metabolism
Signal Transduction
RNA, Circular genetics
RNA, Circular metabolism
Platelet-Derived Growth Factor metabolism
Platelet-Derived Growth Factor genetics
Receptors, Platelet-Derived Growth Factor metabolism
Receptors, Platelet-Derived Growth Factor genetics
Vascular Diseases genetics
Vascular Diseases metabolism
Vascular Diseases therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 14
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 39595622
- Full Text :
- https://doi.org/10.3390/biom14111446