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Enhanced Germinal Center Reactions Within Tertiary Lymphoid Structures Following Neoadjuvant Chemotherapy and Intestinal Care-A Path to Robust Antitumor Immune Response in Borderline Resectable Pancreatic Ductal Adenocarcinoma.
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2024 Oct; Vol. 51 (10), pp. 1038-1043. - Publication Year :
- 2024
-
Abstract
- Background: In 2019, 4 patients with borderline resectable-pancreatic ductal adenocarcinoma(BR-PDAC)received neoadjuvant chemotherapy(NAC)with 3 cycles of gemcitabine plus nab-paclitaxel(GnP)over 12 weeks in combination with intestinal care, and subsequently underwent pancreatectomy. Surprisingly, histological response to NAC was Grade 3(viable tumor cells <10%)in 3 out of 4 patients. Aim/subjects: This study aimed to clarify the histopathological findings common to 3 patients with Grade 3 histological response to NAC.<br />Results: Common histopathological findings were as follows: 1)each tumor bed was extensively replaced by fibrous connective tissues with a high degree of inflammatory cell infiltration, and almost no viable cancer cells were observed; 2)all cancer cells within the perineural space where perineural invasion is usually seen, had undergone cytolysis; 3)tertiary lymphoid structures(TLSs)with germinal centers were found at the periphery of each tumor bed, and many plasma cells were seen adjacent to TLSs; and 4)a lot of tingible body macrophages that phagocytosed apoptotic B cells were present around germinal center.<br />Conclusions: NAC with 3 cycles of GnP over 12 weeks in combination with intestinal care elicited a potent antitumor immune response through enhanced germinal center reactions within TLSs.
- Subjects :
- Humans
Male
Aged
Female
Germinal Center immunology
Middle Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Pancreatectomy
Deoxycytidine analogs & derivatives
Deoxycytidine administration & dosage
Carcinoma, Pancreatic Ductal immunology
Carcinoma, Pancreatic Ductal drug therapy
Carcinoma, Pancreatic Ductal pathology
Carcinoma, Pancreatic Ductal therapy
Carcinoma, Pancreatic Ductal surgery
Neoadjuvant Therapy
Pancreatic Neoplasms immunology
Pancreatic Neoplasms drug therapy
Pancreatic Neoplasms pathology
Pancreatic Neoplasms surgery
Tertiary Lymphoid Structures immunology
Tertiary Lymphoid Structures pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0385-0684
- Volume :
- 51
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 39571990