Palladium-catalyzed cascade cyclization of isocyanides with di-( o -iodophenyl)sulfonylguanidines: access to heterocyclic fused quinazolines.

A palladium-catalyzed cascade cyclization reaction of di- o -iodophenyl sulfonylguanidines with isocyanides for the efficient and selective synthesis of 5- or 6-membered heterocyclic fused quinazolines has been developed. Diverse functional groups are well tolerated, and this method has been successfully applied to a larger scale synthesis.