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Consumption of plant sterols-enriched soy milk with a healthy dietary pattern diet lowers blood pressure in adults with metabolic syndrome: A randomized controlled trial.

Authors :
Xu Y
Sutanto CN
Xia X
Toh DWK
Gan AX
Deng Q
Ling LH
Khoo CM
Foo RS
Kim JE
Source :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2024 Oct 16; Vol. 35 (1), pp. 103773. Date of Electronic Publication: 2024 Oct 16.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Background & Aims: Plant sterols (PS) have been shown to lower blood lipid-lipoproteins concentrations and may serve as a potential functional ingredient for cardiovascular disease (CVD) risk management. However, there are limited studies examining this effect in individuals with metabolic syndrome (MetS). The aim of this study was to evaluate the effects of PS-enriched food consumption as part of a healthy dietary pattern (HDP) on blood pressure and endothelial function in Singaporean adults with MetS.<br />Methods and Results: This was a 12-week, crossover, randomized controlled trial with a 4-week washout period. Thirteen subjects were instructed to consume an HDP diet either with normal soy milk (control group) or with PS (2 g/day)-enriched soy milk (PS group) for 4 weeks. Blood lipid-lipoproteins and glucose concentrations, blood pressure, and endothelial function-related indicators (flow-mediated dilation, total plasma nitrate/nitrite and endothelin-1, circulating endothelial progenitor cells) were assessed before and after the intervention. Systolic blood pressure [mean change, PS group: -4.0 ± 3.7 mmHg; control group: 5.9 ± 2.5 mmHg (P <subscript>Interaction</subscript>  = 0.01)] and long-term CVD risk [mean change, PS group: -0.2 ± 1.0 %; control group: 2.7 ± 1.3 % (P <subscript>Interaction</subscript>  = 0.03)] decreased following PS consumption. No changes were observed in the other endothelial function-related outcomes.<br />Conclusions: Consumption of PS-enriched food with an HDP diet may lower blood pressure and long-term CVD risk in adults with MetS.<br />Clinical Trial Registration: NCT03723330, https://clinicaltrials.gov/.<br />Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.<br /> (Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1590-3729
Volume :
35
Issue :
1
Database :
MEDLINE
Journal :
Nutrition, metabolism, and cardiovascular diseases : NMCD
Publication Type :
Academic Journal
Accession number :
39561689
Full Text :
https://doi.org/10.1016/j.numecd.2024.10.011