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Unveiling the potential of HS-1793: a review of its anticancer properties and therapeutic promise.

Authors :
Capó X
Jiménez-Garcia M
Sharopov F
Tsouh Fokou PV
Martorell M
Aldahish AA
Pezzani R
Sharifi-Rad J
Calina D
Source :
Future medicinal chemistry [Future Med Chem] 2024 Nov 18, pp. 1-11. Date of Electronic Publication: 2024 Nov 18.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

HS-1793 is a novel derivative of resveratrol, a compound known for its numerous beneficial effects, including anticancer activity, anti-inflammatory response, antimicrobial, antiaging, anti-cardiovascular disease activity, neuroprotective activity, etc. Despite its wide and interesting properties, resveratrol suffers from a crucial flaw because it is low bioavailable. For this reason, many other derivatives were explored and among them, HS-1793 has caught the attention of researchers. HS-1793 is a synthetic derivative of resveratrol discovered in 2007 that has been shown to have anti-cancer and anti-inflammatory properties. In addition, the compound showed a positive profile in metabolic processes, with adequate pharmacokinetics and pharmacodynamics. This review highlights current research on HS-1793, evaluating in vitro and in vivo works and lays the foundation for novel explorative trials in human diseases.

Details

Language :
English
ISSN :
1756-8927
Database :
MEDLINE
Journal :
Future medicinal chemistry
Publication Type :
Academic Journal
Accession number :
39555577
Full Text :
https://doi.org/10.1080/17568919.2024.2424150