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Novel HMGA2::COL14A1 Fusion Identified in Xanthogranulomatous Epithelial Tumor/Keratin-Positive Giant Cell Tumor.

Authors :
Dehner CA
Buehler D
Hofich C
Halling KC
Folpe AL
Source :
Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2024 Nov; Vol. 63 (11), pp. e70010.
Publication Year :
2024

Abstract

Xanthogranulomatous epithelial tumor (XGET)/Keratin-positive giant cell tumor (KP-GCT) represents a spectrum of recently described neoplasms characterized by a proliferation of distinctive mononuclear cells expressing keratin within a background of osteoclast-like giant cells, mixed inflammatory cells, and a variably prominent xanthogranulomatous component. Recent studies demonstrated a recurrent HMGA2::NCOR2 fusion in many cases. We herein describe a case of XGET/KP-GCT arising in the right femoral head of a 19-year-old male harboring a rare novel HMGA2::COL14A1 fusion.<br /> (© 2024 Wiley Periodicals LLC.)

Details

Language :
English
ISSN :
1098-2264
Volume :
63
Issue :
11
Database :
MEDLINE
Journal :
Genes, chromosomes & cancer
Publication Type :
Academic Journal
Accession number :
39552601
Full Text :
https://doi.org/10.1002/gcc.70010