Opposite effects of low and high frequency deep brain stimulation of lateral hypothalamus on arousal and temperature in a monkey pilot study.

Deep brain stimulation is a well-established treatment for improving motor symptoms in Parkinson's disease. However, persistent non-motor symptoms, such as excessive daytime sleepiness, remain a significant challenge and necessitate further investigation. In this study, we conducted repeated measurements of daytime sleepiness using a modified multiple sleep latency test in a healthy monkey (macaca fascicularis), which was later rendered parkinsonian through MPTP administration. Deep brain stimulation targeting the lateral hypothalamic area revealed frequency-dependent modulation of both sleepiness level and core body temperature. High-frequency stimulation (80 Hz) increased sleepiness in the healthy state, while low-frequency stimulation (20 Hz) promoted wakefulness in the parkinsonian state. These findings suggest a promising therapeutic approach for addressing sleep/wake disturbances, not only in Parkinson's disease but also in other severe sleep disorders.
Competing Interests: Declarations Competing interests S.Chabardès declares that he has received consultation fees from Medtronic and Boston Scientific in the last 5 years. The other authors declare no competing interests. We used AI to improve readability and language of the work. Ethics approval In accordance with the Grenoble Alpes University, Grenoble Institut of Neurosciences (B3851610008) policies and with French legislation, experiments were performed in compliance with the European Community Council Directive of 2010 (2010/63/UE) for care of laboratory animals and in accordance with the ARRIVE guidelines. All procedures were reviewed and validated by the local ethic committee n˚004 and were authorized by the Direction Départementale des Services Vétérinaires de l’Isère – Ministère de l’Agriculture et de la Pêche, France.
(© 2024. The Author(s).)