A red turn-on fluorescent probe reveals elevated H 2 O 2 in cell anesthesia.

Authors :: Du L
Ning Y
Li W
Kan J
Li J
Wang J
Wang M
Li Y
Zhou J
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Dec 03; Vol. 60 (97), pp. 14443-14446. Date of Electronic Publication: 2024 Dec 03.
Publication Year :: 2024
Abstract: Cognitive dysfunction has become an important central nervous system (CNS)-related adverse reaction of intravenous anesthetics. Therefore, to further understand the role of H <subscript>2</subscript> O <subscript>2</subscript> , a potential marker of cognitive dysfunction, we constructed a fluorescent probe (LJ-1), which could specifically enable real-time detection of H <subscript>2</subscript> O <subscript>2</subscript> in cells during anesthesia.