The synthesis and antileukemic activity of 5-substituted thiazolyl urea derivatives.

Authors :: Peng C
Sheng L
Xu GY
Qi XL
Zhou YB
Jia-Li
Cui YM
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 12; Vol. 115, pp. 130018. Date of Electronic Publication: 2024 Nov 12.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: A series of novel 5-substituted thiazolyl urea derivatives were synthesized and evaluated for their efficacy as antileukemic agents against two human leukemic cell lines (THP-1 and MV-4-11). Results showed that the activities of the investigated compounds were quite sensitive to the positions and properties of the aromatic substituents. Among these compounds, compound 12k showed the highest activity with IC <subscript>50</subscript> values of 29 ± 0.3 nM for THP-1 cells and 98 ± 10 nM for MV-4-11 cells.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)

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