Synthesis and antimycotic activity of new derivatives of imidazo[1,2- a ]pyrimidines.

The heterocyclic core of imidazo[1,2- a ]pyrimidine was formed in satisfactory yields as a result of the interaction of the readily available 2-aminoimidazole with N -substituted maleimides or N -arylitaconimides. The mechanism of the studied processes was postulated basing on experimental data, HPLC-MS analysis of reaction mixtures, and quantum chemical calculations. Molecular docking results of the obtained imidazo[1,2- a ]pyrimidines, when compared with voriconazole, a drug already in clinical use, suggest that they may possess antifungal activity against Candida albicans .
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