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Decompression Illness After Technical Diving Session in Mediterranean Sea: Oxidative Stress, Inflammation, and HBO Therapy.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 Oct 22; Vol. 25 (21). Date of Electronic Publication: 2024 Oct 22. - Publication Year :
- 2024
-
Abstract
- SCUBA diving poses risks due to pressure changes during descent (compression) and ascent (decompression). Decompression sickness (DCS) occurs due to gas bubble formation as the pressure decreases, causing joint pain, numbness, dizziness, or even paralysis and death. Immediate treatment involves 100% oxygen to help eliminate inert gases and hyperbaric oxygen therapy (HBOT), which is essential to reduce gas emboli formation and inflammation, thus improving symptoms. We evaluated oxy-inflammation biomarkers in the saliva and urine of nine subjects pre- and post-technical dive on the Haven wreck (GE, Italy). A case of DCS occurred during the dive. The injured diver was treated immediately with O <subscript>2</subscript> and transported to the hyperbaric center of "ASST Ospedale Ca Granda" in Milan. He was treated following the U.S. Navy Treatment Table 5 at 2.8 ATA and the day after with Table 15 at 2.4 ATA. Venous blood and urine samples were collected before and after each HBO treatment. Our study shows that dive increased oxy-inflammation biomarkers (ROS +126%; lipid peroxidation +23%; interleukins-6 +81%, -1β +19%, and TNFα +84%) and nitric oxide metabolites levels (+36%). HBOT after a DCS episode reduced oxidative stress, lowering the very high marker of lipid peroxidation (8-iso-PGF2α), and inhibited inflammatory interleukins. Overall, HBOT improved physiological responses in the diver affected by DCS.
- Subjects :
- Humans
Male
Adult
Mediterranean Sea
Middle Aged
Lipid Peroxidation
Decompression Sickness therapy
Decompression Sickness etiology
Decompression Sickness metabolism
Decompression Sickness blood
Oxidative Stress
Hyperbaric Oxygenation methods
Diving adverse effects
Diving physiology
Inflammation therapy
Inflammation metabolism
Inflammation etiology
Biomarkers urine
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 39518919
- Full Text :
- https://doi.org/10.3390/ijms252111367