Effects of loxoprofen on impaired water-evoked swallows in a pharyngitis rat model.

Objective: The objective of this study was to investigate the effects of nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., loxoprofen) on pharyngitis-induced dysphagia in rats.
Design: A pharyngitis rat model was generated by topical application of acetic acid to the laryngopharyngeal region. Changes in water swallowing were evaluated by endoscopic observation over time. A histological analysis of the laryngopharyngeal mucosa was performed. The effects of loxoprofen, antibacterial drugs, and transient receptor potential (TRP) channel inhibitors were investigated in model rats.
Results: After acetic acid treatment, water-evoked swallowing was impaired on day 1 (prolonging the swallowing latency and interval and decreasing the number of swallows), and recovered until day 6. Administration of loxoprofen significantly alleviated impaired water swallowing. Histologically, loxoprofen significantly improved inflammation of the pharynx, including submucosal edema, but did not affect the loss of taste bud-like structures in the arytenoid. In contrast, the administration of antibacterial drugs or TRP channel inhibitors did not affect the impairment of water swallowing in the model group.
Conclusion: These results demonstrate the efficacy of systemic administration of loxoprofen in improving swallowing impairment in a pharyngitis model rat. This study is the first to provide scientific evidence for the use of NSAIDs in the management of pharyngitis.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Chihiro Nakatomi reports financial support was provided by Daiichi Sankyo Healthcare Co Ltd. Sayaka Kubo reports a relationship with Daiichi Sankyo Healthcare Co Ltd that includes: employment. Tomoki Shimada reports a relationship with Daiichi Sankyo Healthcare Co Ltd that includes: employment. Keiko Tsuji reports a relationship with Daiichi Sankyo Healthcare Co Ltd that includes: employment. Sayaka Kubo, Tomoki Shimada, Keiko Tsuji has patent pending to Japan Patent Office. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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