Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer.

Authors :: Dimitrieva S
Harrison JM
Chang J
Piquet M
Mino-Kenudson M
Gabriel M
Sagar V
Horn H
Lage K
Kim J
Li G
Weng S
Harris C
Kulkarni AS
Ting DT
Qadan M
Fagenholz PJ
Ferrone CR
Grauel AL
Laszewski T
Raza A
Riester M
Somerville T
Wagner JP
Dranoff G
Engelman JA
Kauffmann A
Leary R
Warshaw AL
Lillemoe KD
Fernández-Del Castillo C
Ruddy DA
Liss AS
Cremasco V
Source :: Cancer research communications [Cancer Res Commun] 2024 Dec 01; Vol. 4 (12), pp. 3049-3066.
Publication Year :: 2024
Abstract: Significance: Pancreatic cancer remains a high unmet medical need. Understanding the interactions between stroma and cancer cells in this disease may unveil new opportunities for therapeutic intervention.<br /> (©2024 The Authors; Published by the American Association for Cancer Research.)

Subjects :: Humans
Sequence Analysis, RNA methods
Tumor Microenvironment genetics
Fibroblasts pathology
Fibroblasts metabolism
Pancreatic Neoplasms genetics
Pancreatic Neoplasms pathology
Single-Cell Analysis methods

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