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Tumour Immunotherapy and Applications of Immunological Products: A Review of Literature.

Tumour Immunotherapy and Applications of Immunological Products: A Review of Literature.

Authors :
Oli AN
Adejumo SA
Rowaiye AB
Ogidigo JO
Hampton-Marcell J
Ibeanu GC
Source :
Journal of immunology research [J Immunol Res] 2024 Oct 24; Vol. 2024, pp. 8481761. Date of Electronic Publication: 2024 Oct 24 (Print Publication: 2024).
Publication Year :
2024

Abstract

Malignant tumors, characterized by uncontrolled cell proliferation, are a leading global health challenge, responsible for over 9.7 million deaths in 2022, with new cases expected to rise to 35 million annually by 2050. Immunotherapy is preferred to other cancer therapies, offering precise targeting of malignant cells while simultaneously strengthening the immune system's complex responses. Advances in this novel field of science have been closely linked to a deeper knowledge of tumor biology, particularly the intricate interplay between tumor cells, the immune system, and the tumor microenvironment (TME), which are central to cancer progression and immune evasion. This review offers a comprehensive analysis of the molecular mechanisms that govern these interactions, emphasizing their critical role in the development of effective immunotherapeutic products. We critically evaluate the current immunotherapy approaches, including cancer vaccines, adoptive T cell therapies, and cytokine-based treatments, highlighting their efficacy and safety. We also explore the latest advancements in combination therapies, which synergistically integrate multiple immunotherapeutic strategies to overcome resistance and enhance therapeutic outcomes. This review offers key insights into the future of cancer immunotherapy with a focus on advancing more effective and personalized treatment strategies.<br />Competing Interests: The authors declare no conflicts of interest.<br /> (Copyright © 2024 Angus Nnamdi Oli et al.)

Details

Language :
English
ISSN :
2314-7156
Volume :
2024
Database :
MEDLINE
Journal :
Journal of immunology research
Publication Type :
Academic Journal
Accession number :
39483536
Full Text :
https://doi.org/10.1155/2024/8481761