A Mixed Electrical and Chemical Synapse in the Thalamic Reticular Nucleus.

The thalamic reticular nucleus (TRN) plays a major role in modulating the transfer of information from the thalamus to the cortex. GABAergic inhibition by the TRN is potentially synchronized by electrical synapses between TRN neurons, and TRN neurons are also sparsely connected to each other via chemical synapses. Paired recordings have shown that electrical coupling is abundant between TRN neurons, especially amongst those within close proximity, but no combined electrical and chemical coupling has been directly demonstrated in rats. Here, we report on a single pair of TRN neurons that were coupled both electrically and chemically. This is the only such example that we have found in hundreds of paired recordings of closely apposed neurons within the TRN.