Obesity-dependent selection of driver mutations in cancer.

Authors :: Tang C
Castillon VJ
Waters M
Fong C
Park T
Boscenco S
Kim S
Pekala K
Carrot-Zhang J
Hakimi AA
Schultz N
Ostrovnaya I
Gusev A
Jee J
Reznik E
Source :: Nature genetics [Nat Genet] 2024 Nov; Vol. 56 (11), pp. 2318-2321. Date of Electronic Publication: 2024 Oct 28.
Publication Year :: 2024
Abstract: Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma and cancers of unknown primaries, independent of clinical covariates, demographic factors and genetic ancestry. Obesity is therefore a driver of etiological heterogeneity in some cancers.<br /> (© 2024. The Author(s).)