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Impact of mitochondrial dysfunction on the antitumor effects of immune cells.

Authors :
Wang Q
Yin X
Huang X
Zhang L
Lu H
Source :
Frontiers in immunology [Front Immunol] 2024 Oct 11; Vol. 15, pp. 1428596. Date of Electronic Publication: 2024 Oct 11 (Print Publication: 2024).
Publication Year :
2024

Abstract

Mitochondrial dysfunction, a hallmark of immune cell failure, affects the antitumor effects of immune cells through metabolic reprogramming, fission, fusion, biogenesis, and immune checkpoint signal transduction of mitochondria. According to researchers, restoring damaged mitochondrial function can enhance the efficacy of immune cells. Nevertheless, the mechanism of mitochondrial dysfunction in immune cells in patients with cancer is unclear. In this review, we recapitulate the impact of mitochondrial dysfunction on the antitumor effects of T cells, natural killer cells, dendritic cells, and tumor-associated macrophage and propose that targeting mitochondria can provide new strategies for antitumor therapy.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Wang, Yin, Huang, Zhang and Lu.)

Details

Language :
English
ISSN :
1664-3224
Volume :
15
Database :
MEDLINE
Journal :
Frontiers in immunology
Publication Type :
Academic Journal
Accession number :
39464876
Full Text :
https://doi.org/10.3389/fimmu.2024.1428596