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Impact of mitochondrial dysfunction on the antitumor effects of immune cells.
- Source :
-
Frontiers in immunology [Front Immunol] 2024 Oct 11; Vol. 15, pp. 1428596. Date of Electronic Publication: 2024 Oct 11 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Mitochondrial dysfunction, a hallmark of immune cell failure, affects the antitumor effects of immune cells through metabolic reprogramming, fission, fusion, biogenesis, and immune checkpoint signal transduction of mitochondria. According to researchers, restoring damaged mitochondrial function can enhance the efficacy of immune cells. Nevertheless, the mechanism of mitochondrial dysfunction in immune cells in patients with cancer is unclear. In this review, we recapitulate the impact of mitochondrial dysfunction on the antitumor effects of T cells, natural killer cells, dendritic cells, and tumor-associated macrophage and propose that targeting mitochondria can provide new strategies for antitumor therapy.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Wang, Yin, Huang, Zhang and Lu.)
- Subjects :
- Humans
Animals
Dendritic Cells immunology
Killer Cells, Natural immunology
T-Lymphocytes immunology
T-Lymphocytes metabolism
Tumor-Associated Macrophages immunology
Tumor-Associated Macrophages metabolism
Immunotherapy methods
Signal Transduction
Mitochondria metabolism
Mitochondria immunology
Neoplasms immunology
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 39464876
- Full Text :
- https://doi.org/10.3389/fimmu.2024.1428596