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The Association Between Preoperative Sarcopenia and Sarcopenic Obesity and the Occurrence of Postoperative Complications in Patients Undergoing Pancreaticoduodenectomy for Periampullary Malignancies-A Literature Review.
- Source :
-
Nutrients [Nutrients] 2024 Oct 21; Vol. 16 (20). Date of Electronic Publication: 2024 Oct 21. - Publication Year :
- 2024
-
Abstract
- Background: Sarcopenia and sarcopenic obesity, perceived as a reflection of cancer-induced cachexia, are often diagnosed in patients with periampullary malignancies. The pathophysiology of those conditions is multifactorial regarding the tumor microenvironment, immunological response, and the relationship to surrounding tissues.<br />Methods: The PubMed and SCOPUS databases were systematically searched between November 2023 and December 2023. A total of 254 studies were primarily identified. Regarding the inclusion and exclusion criteria, 26 studies were finally included in the review.<br />Results: Evaluated papers disclosed that sarcopenia was significantly associated with a higher incidence of postoperative complications, including pancreatic fistula (POPF) type B and C, with the odds ratio (OR) ranging from 2.65 (95%CI 1.43-4.93, p = 0.002) to 4.30 (95%CI 1.15-16.01, p < 0.03). Sarcopenic patients also suffered more often from delayed gastric emptying (DGE) with an OR of 6.04 (95%CI 1.13-32.32, p = 0.036). Infectious complications, postoperative hemorrhage, and intra-abdominal abscesses occurred more often in sarcopenic patients. Surgical complications were also noted more frequently when sarcopenic obesity was present. Preoperative nutritional prehabilitation seems to reduce the risk of postoperative complications. However, more prospective studies are needed.<br />Conclusions: Sarcopenia and sarcopenic obesity were associated with a higher incidence of multiple postoperative complications, including POPF (type B and C), DGE, hemorrhage, and infectious complications.
- Subjects :
- Humans
Incidence
Female
Male
Pancreatic Fistula epidemiology
Pancreatic Fistula etiology
Aged
Middle Aged
Preoperative Period
Risk Factors
Gastric Emptying
Common Bile Duct Neoplasms surgery
Common Bile Duct Neoplasms complications
Sarcopenia epidemiology
Sarcopenia complications
Sarcopenia etiology
Postoperative Complications epidemiology
Postoperative Complications etiology
Pancreaticoduodenectomy adverse effects
Obesity complications
Obesity surgery
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 16
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 39458563
- Full Text :
- https://doi.org/10.3390/nu16203569