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Influence of Common Gene Variants on Lipid Levels and Risk of Coronary Heart Disease in Afro-Caribbeans.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 Oct 17; Vol. 25 (20). Date of Electronic Publication: 2024 Oct 17. - Publication Year :
- 2024
-
Abstract
- A lower mortality rate from coronary artery disease (CAD) and a more favourable lipid profile have been reported in Afro-Caribbeans compared with people of European ancestry. The aim of this study was to determine whether common lipid variants identified in other populations are associated with lipid levels and CAD in Afro-Caribbeans. We studied 705 Afro-Caribbeans (192 with CAD) who were genotyped for 13 lipid-associated variants. We calculated three polygenic risk scores (PRSs) for elevated LDL (LDL-PRS), decreased HDL (HDL-PRS), and elevated triglycerides (TG-PRS). LDL-PRS, HDL-PRS, and TG-PRS were associated with LDL, HDL, and TG levels, respectively. The LDL-PRS was positively associated with LDL > 2.6 mmol/L and with LDL > 3.0 mmol/L with ORs (odds ratios) of 1.33 (95% confidence interval (CI) = 1.14-1.56) and 1.40 (CI = 1.21-1.62), respectively. The HDL-PRS was associated with a low HDL category (HDL < 1.03 mmol/L) with an OR of 1.3 (CI = 1.04-1.63) and inversely associated with a high HDL category (HDL > 1.55 mmol/L) with an OR of 0.79 (CI = 0.65-0.96). The LDL-PRS was positively associated with CAD after adjustment for age, gender, hypertension, diabetes, and smoking with an OR of 1.27 (CI = 1.06-1.51) but not the HDL-PRS nor the TG-PRS. Results of the present study indicate that common lipid variants are associated with lipid levels and prevalent CAD in Afro-Caribbeans.
- Subjects :
- Humans
Female
Male
Middle Aged
Coronary Artery Disease genetics
Coronary Artery Disease blood
Coronary Artery Disease epidemiology
Polymorphism, Single Nucleotide
Aged
Triglycerides blood
Lipids blood
Risk Factors
Caribbean Region
Coronary Disease genetics
Coronary Disease blood
Coronary Disease epidemiology
Cholesterol, HDL blood
Cholesterol, LDL blood
Caribbean People
Black People genetics
Genetic Predisposition to Disease
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 39456920
- Full Text :
- https://doi.org/10.3390/ijms252011140