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Penicitrisochromans A-C, new isochromans from the marine-derived fungus Penicillium citrinum PSU-MF100.

Authors :
Thamsiri P
Rukachaisirikul V
Phongpaichit S
Preedanon S
Sakayaroj J
Muanprasat C
Hadsadee S
Jungsuttiwong S
Source :
Natural product research [Nat Prod Res] 2024 Oct 20, pp. 1-7. Date of Electronic Publication: 2024 Oct 20.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Three new isochroman derivatives, penicitrisochromans A-C ( 1 - 3 ), together with 25 known polyketides were isolated from the marine-derived fungus Penicillium citrinum PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of 3 were assigned based on the ECD calculation and biosynthetic consideration. Among the isolated polyketides, three known anthraquinone derivatives, ω -hydroxyemodin, penicillanthranin A and emodin, displayed moderate to strong antibacterial activity against methicillin-resistant Staphylococcus aureus with MIC values of 32, 16 and 4  µ g/mL, respectively. For antifungal activity, two known benzopyranones, coniochaetones A and C, exhibited moderate antifungal activity against Candida albicans NCPF3153 and Cryptococcus neoformans ATCC90112 with the respective MIC values of 16 and 64  µ g/mL.

Details

Language :
English
ISSN :
1478-6427
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
39428755
Full Text :
https://doi.org/10.1080/14786419.2024.2416515