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From ROS scavenging to boosted osseointegration: cerium-containing mesoporous bioactive glass nanoparticles functionalized implants in diabetes.
- Source :
-
Journal of nanobiotechnology [J Nanobiotechnology] 2024 Oct 18; Vol. 22 (1), pp. 639. Date of Electronic Publication: 2024 Oct 18. - Publication Year :
- 2024
-
Abstract
- Excessive production of reactive oxygen species (ROS) around titanium implants under diabetic conditions causes persistent inflammation, leading to poor osseointegration and even implant failure. Surface modification is an effective way to promote ROS clearance, alleviate inflammation, and stimulate bone formation. In this study, a multifunctional coating is fabricated by introducing cerium (Ce)-containing mesoporous bioactive glass nanoparticles (Ce-MBGNs) onto the titanium surface via an electrophoretic deposition method. The incorporation of Ce-MBGNs remarkably improves surface hydrophilicity by increasing the surface areas. The bioactive ions are appropriately released, thereby promoting mesenchymal stem cell proliferation and differentiation under diabetic conditions. The conversion between Ce(III) and Ce(IV) endows Ce-MBGNs coating with antioxidative nanoenzymes properties to scavenge diabetes-induced ROS, resulting in macrophage polarization towards the anti-inflammatory phenotype. The therapeutic effect of Ce-MBGNs-modified titanium implants is also verified in diabetic rats by inhibiting inflammatory responses and accelerating early osseointegration. Taken together, the findings reveal that the ROS-scavenging and immunomodulation activity of the Ce-MBGNs coating contributes to enhanced osseointegration, and provides a novel implant surface for diabetic patients.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Rats
Male
Rats, Sprague-Dawley
Prostheses and Implants
Surface Properties
Porosity
Cell Proliferation drug effects
Cell Differentiation drug effects
Mice
Coated Materials, Biocompatible chemistry
Coated Materials, Biocompatible pharmacology
Free Radical Scavengers pharmacology
Free Radical Scavengers chemistry
Cerium chemistry
Cerium pharmacology
Osseointegration drug effects
Reactive Oxygen Species metabolism
Diabetes Mellitus, Experimental
Titanium chemistry
Titanium pharmacology
Nanoparticles chemistry
Mesenchymal Stem Cells metabolism
Mesenchymal Stem Cells drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1477-3155
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of nanobiotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 39425200
- Full Text :
- https://doi.org/10.1186/s12951-024-02865-y