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[Evaluation of various administration routes of the streptococcal preparation, OK-432, with regard to their in vivo effect by lymphocytes proliferation assay].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1986 Jan; Vol. 13 (1), pp. 95-100. - Publication Year :
- 1986
-
Abstract
- To evaluate the efficacies of various administration routes of the streptococcal preparation, OK-432, we studied the lymphocyte proliferation responses to lectins in patients with malignancies. OK-432 was administered intravenously (I.V.), intramuscularly (I. M.) or intradermally (I.D.) for 2 weeks. Lymphocyte proliferation responses to concanavalin A, PHA and SuM (crude extract of OK-432) were studied before and after OK-432 administration. Enhanced responses were observed in 7 out of 9 patients (77.8%) in the I.V. group compared with 3 out of 7 (44.2%) in the I.M. group and 4 out of 9 (44.4%) in the I.D. group. Ratios of stimulation index (S.I.) after administration over S.I. before administration were highest in the I.V. group. These results suggest that I.V. administration of OK-432 is most effective for stimulating host immune systems.
- Subjects :
- Adenocarcinoma immunology
Adult
Aged
Carcinoma, Squamous Cell immunology
Concanavalin A pharmacology
Female
Humans
Infusions, Parenteral
Male
Middle Aged
Phytohemagglutinins pharmacology
Picibanil immunology
Biological Products administration & dosage
Lung Neoplasms immunology
Lymphocyte Activation
Picibanil administration & dosage
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 3942400