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Stalling out chromatin machinery-Oncohistone mutation disrupts heterochromatin memory.
- Source :
-
Molecular cell [Mol Cell] 2024 Oct 17; Vol. 84 (20), pp. 3861-3862. - Publication Year :
- 2024
-
Abstract
- In this issue, Sinha et al. <superscript>1</superscript> use cellular chromatin reporter assays along with CRISPR gene editing to reveal that the histone H3.3K36M oncohistone mutation disrupts epigenetic memory and stability of H3K9me3 domains by blocking transitions into a stably repressed state.<br />Competing Interests: Declaration of interests N.A.H. is a founder and shareholder of Epigenos Biosciences, Inc.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-4164
- Volume :
- 84
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Molecular cell
- Publication Type :
- Academic Journal
- Accession number :
- 39423792
- Full Text :
- https://doi.org/10.1016/j.molcel.2024.09.028