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Correlation between lncRNAs with human molecular chaperons in cancer immunopathogenesis and drug resistance.

Authors :
Hsu CY
Hisham Ateya N
Felix Oghenemaro E
Nathiya D
Kaur P
Hjazi A
Eldesoqui M
Yumashev A
Kadhim Abosaoda M
Adnan Abdulrahman M
Source :
International immunopharmacology [Int Immunopharmacol] 2024 Dec 25; Vol. 143 (Pt 1), pp. 113309. Date of Electronic Publication: 2024 Oct 14.
Publication Year :
2024

Abstract

The development of cancer immunology heavily relies on the interaction between long non-coding RNAs (lncRNAs) and molecular chaperones. By participating in gene regulation, lncRNAs interact with molecular chaperones, which play a critical role in protein folding and stress responses, to influence oncogenic pathways. This interaction has an impact on both the immune cells within the tumor microenvironment and the tumor cells themselves. Understanding these mechanisms provides valuable insights into innovative approaches for diagnosis and treatment. Targeting the lncRNA-chaperone axis has the potential to strengthen anti-tumor immunity and enhance cancer treatment outcomes. Further research is necessary to uncover specific associations, identify biomarkers, and develop personalized therapies aimed at disrupting this axis, which could potentially revolutionize cancer diagnosis and treatment.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1878-1705
Volume :
143
Issue :
Pt 1
Database :
MEDLINE
Journal :
International immunopharmacology
Publication Type :
Academic Journal
Accession number :
39405942
Full Text :
https://doi.org/10.1016/j.intimp.2024.113309