68Ga-DOTATATE and 18F-FDG PET/CT in a Rapidly Progressing Lymphoma.

Authors :: Parihar AS
Wahl RL
Jahromi AH
Source :: Clinical nuclear medicine [Clin Nucl Med] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: Abstract: 68Ga-DOTATATE PET/CT targeting somatostatin receptors is commonly utilized in the imaging of neuroendocrine tumors. However, other malignancies such as lymphomas (both Hodgkin and non-Hodgkin) also have expression of somatostatin receptors, albeit to a lesser degree compared with the neuroendocrine tumors, and thus can be positive on a 68Ga-DOTATATE PET/CT. We describe an atypical presentation of an aggressive large B-cell lymphoma mimicking a metastatic neuroendocrine tumor at initial presentation with high somatostatin receptor expression demonstrated on the 68Ga-DOTATATE PET/CT and a rapidly progressing course on the subsequent 18F-FDG PET/CT.<br />Competing Interests: Conflicts of interest and sources of funding: None.<br /> (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)