Hematological causes of acute ischemic stroke in younger individuals.

Ischemic stroke is a common cause of morbidity and mortality worldwide. The majority of affected individuals are older, with clear cardiovascular or embolic risk factors; however, up to a fifth of cases may occur in patients under the age of 50 years. In this review, we discuss some common hematological causes of ischemic stroke in this age range, with a focus on antiphospholipid syndrome, myeloproliferative neoplasms, immune thrombocytopenic purpura, and sickle cell disease. We review the etiology of stroke associated with these conditions and explore important management considerations that may be unique to these settings. These include the choice of antithrombotic agents, cytoreduction in myeloproliferative neoplasms, management of thrombocytopenia in immune thrombocytopenic purpura, and treatment of sickle cell disease.
Competing Interests: Declaration of competing interests G.O.: none; D.S.: none; J.M.C.: research funding: CSL Behring; consultancy fees: Abbott; honoraria: Bristol Myers Squibb, Roche, and Sanofi: advisory boards: Abbott, Alnylam, Anthos, Bristol Myers Squibb, Sanofi, and Takeda; J.T.: honoraria: LeoPharma, Bayer, BMS-Pfizer, Boehringer, and Daichii.
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