Back to Search
Start Over
A genome-wide association study of neonatal metabolites.
- Source :
-
Cell genomics [Cell Genom] 2024 Oct 09; Vol. 4 (10), pp. 100668. - Publication Year :
- 2024
-
Abstract
- Genetic factors significantly influence the concentration of metabolites in adults. Nevertheless, the genetic influence on neonatal metabolites remains uncertain. To bridge this gap, we employed genotype imputation techniques on large-scale low-pass genome data obtained from non-invasive prenatal testing. Subsequently, we conducted association studies on a total of 75 metabolic components in neonates. The study identified 19 previously reported associations and 11 novel associations between single-nucleotide polymorphisms and metabolic components. These associations were initially found in the discovery cohort (8,744 participants) and subsequently confirmed in a replication cohort (19,041 participants). The average heritability of metabolic components was estimated to be 76.2%, with a range of 69%-78.8%. These findings offer valuable insights into the genetic architecture of neonatal metabolism.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 2666-979X
- Volume :
- 4
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cell genomics
- Publication Type :
- Academic Journal
- Accession number :
- 39389019
- Full Text :
- https://doi.org/10.1016/j.xgen.2024.100668