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Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury.
- Source :
-
BMC molecular and cell biology [BMC Mol Cell Biol] 2024 Oct 09; Vol. 25 (1), pp. 22. Date of Electronic Publication: 2024 Oct 09. - Publication Year :
- 2024
-
Abstract
- Retinal ischemia-reperfusion (IR) injury is a basic pathological procedure in clinic and associated with various ischemic retinal diseases, including glaucoma, diabetic retinopathy, retinal vascular occlusion, etc. The purpose of this work is to investigate the effect of ciclopirox olamine (CPX) on retinal IR injury and further explore the underlying mechanism. In vitro assay exhibited that CPX exhibited significant neuroprotection against oxygen glucose deprivation (OGD) and oxidative stress-induced injuries in 661W photoreceptor cells. OGD injury showed a proinflammatory phenotype characterized by significantly increased production of cytokines (IL-6, IL-23 and TNF-α), while CPX significantly inhibited their secretion. In addition, the in vivo experiment demonstrated that CPX significantly preserved the normal thickness of the retina. Therefore, we suggest that CPX is identified in our research as a prospective therapeutic agent for retinal IR injury.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Mice
Retina drug effects
Retina metabolism
Retina pathology
Cytokines metabolism
Glucose metabolism
Cell Line
Retinal Diseases drug therapy
Retinal Diseases metabolism
Male
Mice, Inbred C57BL
Photoreceptor Cells, Vertebrate drug effects
Photoreceptor Cells, Vertebrate metabolism
Photoreceptor Cells, Vertebrate pathology
Ciclopirox pharmacology
Ciclopirox therapeutic use
Reperfusion Injury drug therapy
Reperfusion Injury metabolism
Neuroprotective Agents pharmacology
Neuroprotective Agents therapeutic use
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2661-8850
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC molecular and cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 39385121
- Full Text :
- https://doi.org/10.1186/s12860-024-00520-w