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Towards an update on the antimicrobial use in Adult Care Units in Brazil: insights from multi-hospital prevalence study.
- Source :
-
Journal of medical microbiology [J Med Microbiol] 2024 Oct; Vol. 73 (10). - Publication Year :
- 2024
-
Abstract
- Introduction. Efforts to understand the burden of antibiotic use in low- and middle-income countries such as Brazil are essential for developing strategies that are effective and appropriate in the context of endemic multidrug-resistant organisms. Aim. This study aims to determine antimicrobial-prescribing practices among patients hospitalized in intensive care units (ICUs) for adults in Brazil. Methodology. A 1-day point prevalence multicentre survey was conducted in 58 adult ICUs across the five regions of Brazil. The institutions were categorized according to their type and size. Detailed antimicrobial prescription data were prospectively provided to all patients hospitalized on the day of data collection. Results. A total of 620 patients were included in the study, of whom 63.9% were receiving at least one antimicrobial. Of these, 34.6% were treated for an infection, but only 39.9% of the cases were based on microbiological criteria. Empirical treatment was applied to 72.3% of the patients. Significant differences in antibiotic usage were observed across the different hospitals included in the study. Overall, treatment was most commonly directed towards pneumonia (51.8%) and bloodstream infections (29.6%). Glycopeptides (19.4%) and carbapenems (18.5%) were the most prescribed in teaching hospitals, while in non-teaching hospitals, carbapenems (17.8%) and broad-spectrum cephalosporins (16.8%) were most frequently used. Conclusion. Our study reveals alarming data on antibiotic use in adult ICUs in Brazil, with high frequencies of severe healthcare-associated infections acquired in these units, where patients are frequently subjected to empirical treatment.
- Subjects :
- Humans
Brazil epidemiology
Male
Adult
Female
Middle Aged
Aged
Prevalence
Prospective Studies
Drug Utilization statistics & numerical data
Antimicrobial Stewardship
Young Adult
Hospitals statistics & numerical data
Aged, 80 and over
Intensive Care Units statistics & numerical data
Anti-Bacterial Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5644
- Volume :
- 73
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 39382961
- Full Text :
- https://doi.org/10.1099/jmm.0.001908