Back to Search
Start Over
Histone lactylation drives CD8 + T cell metabolism and function.
- Source :
-
Nature immunology [Nat Immunol] 2024 Nov; Vol. 25 (11), pp. 2140-2151. Date of Electronic Publication: 2024 Oct 07. - Publication Year :
- 2024
-
Abstract
- The activation and functional differentiation of CD8 <superscript>+</superscript> T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone lactylation in the context of CD8 <superscript>+</superscript> T cell activation and function is not known. Here, we show the enrichment of H3K18 lactylation (H3K18la) and H3K9 lactylation (H3K9la) in human and mouse CD8 <superscript>+</superscript> T cells, which act as transcription initiators of key genes regulating CD8 <superscript>+</superscript> T cell function. Further, we note distinct patterns of H3K18la and H3K9la in CD8 <superscript>+</superscript> T cell subsets linked to their specific metabolic profiles. Additionally, we find that modulation of H3K18la and H3K9la by targeting metabolic and epigenetic pathways influence CD8 <superscript>+</superscript> T cell effector function, including antitumor immunity, in preclinical models. Overall, our study uncovers the potential roles of H3K18la and H3K9la in CD8 <superscript>+</superscript> T cells.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 39375549
- Full Text :
- https://doi.org/10.1038/s41590-024-01985-9