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Altered corticalfunctional networks in Wilson's disease: A resting-state electroencephalogram study.

Authors :
Chen RK
Zhang C
Lin JW
Shi WX
Li YR
Chen WJ
Cai NQ
Source :
Neurobiology of disease [Neurobiol Dis] 2024 Oct 05; Vol. 202, pp. 106692. Date of Electronic Publication: 2024 Oct 05.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

The neuropsychiatric symptoms are common in Wilson's disease (WD) patients. However, it remains unclear about the associated functional brain networks. In this study, source localization-based functional connectivity analysis of close-eye resting-state electroencephalography (EEG) were implemented to assess the characteristics of functional networks in 17 WD patients with neurological involvements and 17 healthy controls (HCs). The weighted phase-lag index (wPLI) was subsequently calculated in source space across five different frequency bands and the resulting connectivity matrix was transformed into a weighted graph whose structure was measured by five graphical analysis indicators, which were finally correlated with clinical scores. Compared to HCs, WD patients revealed disconnected sub-networks in delta, theta and alpha bands. Moreover, WD patients exhibited significantly reduced global clustering coefficients and small-worldness in all five frequency bands. In WD group, the severity of neurological symptoms and structural brain abnormalities were significantly correlated with disrupted functional networks. In conclusion, our study demonstrated that functional network deficits in WD can reflect the severity of their neurological symptoms and structural brain abnormalities. Resting-state EEG may be used as a marker of brain injury in WD.<br />Competing Interests: Declaration of competing interest None of the authors have potential conflicts of interest to be disclosed.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1095-953X
Volume :
202
Database :
MEDLINE
Journal :
Neurobiology of disease
Publication Type :
Academic Journal
Accession number :
39370050
Full Text :
https://doi.org/10.1016/j.nbd.2024.106692