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Advanced glycation end products promote ROS production via PKC/p47 phox axis in skeletal muscle cells.
- Source :
-
The journal of physiological sciences : JPS [J Physiol Sci] 2024 Oct 05; Vol. 74 (1), pp. 51. Date of Electronic Publication: 2024 Oct 05. - Publication Year :
- 2024
-
Abstract
- Advanced glycation end products (AGEs) are risk factors for various diseases, including sarcopenia. One of the deleterious effects of AGEs is the induction of abnormal reactive oxygen species (ROS) production in skeletal muscle. However, the underlying mechanism remains poorly understood. Therefore, the aim of this study was to elucidate how AGEs induce ROS production in skeletal muscle cells. This study demonstrated that AGEs treatment promoted ROS production in myoblasts and myotubes while PKC inhibitor abolished ROS production by AGEs stimulation. Phosphorylation of p47 phox by kinases such as PKCα is required to form the Nox2 complex, which induces ROS production. In this study, AGEs treatment promoted the phosphorylation of PKCα and p47 phox in myoblasts and myotubes. Our findings suggest that AGEs promote ROS production through the phosphorylation of PKCα and p47 phox in skeletal muscle cells.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Mice
Phosphorylation
Myoblasts metabolism
Myoblasts drug effects
Protein Kinase C metabolism
Cell Line
Protein Kinase C-alpha metabolism
Signal Transduction physiology
Signal Transduction drug effects
Glycation End Products, Advanced metabolism
Reactive Oxygen Species metabolism
Muscle Fibers, Skeletal metabolism
Muscle Fibers, Skeletal drug effects
NADPH Oxidases metabolism
Muscle, Skeletal metabolism
Muscle, Skeletal drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1880-6562
- Volume :
- 74
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The journal of physiological sciences : JPS
- Publication Type :
- Academic Journal
- Accession number :
- 39369187
- Full Text :
- https://doi.org/10.1186/s12576-024-00944-1