Butin Protects Keratinocytes From Particulate Matter 2.5 and Ultraviolet B-Mediated Damages.

Background: Butin is a naturally occurring compound with a wide range of medicinal properties, including anti-inflammatory, anti-arthritic, and antioxidant properties. Particulate matter 2.5 (PM _2.5 ) and ultraviolet B (UVB) radiation contribute to skin cell damage via the induction of oxidative stress.
Methods: This study sought to assess the protective effects of butin against damage triggered by PM _2.5 and UVB in human HaCaT keratinocytes. Assessments were performed to evaluate cell viability, apoptosis, and cellular component damage.
Results: Butin exhibited its protective ability via the inhibition of PM _2.5 -induced reactive oxygen species generation, lipid peroxidation, DNA damage, protein carbonylation, and mitochondrial damage. Butin reduced the PM _2.5 -induced c-Fos and phospho-c-Jun protein levels as well as mitogen-activated protein kinase. Furthermore, butin mitigated PM _2.5 - and UVB-induced apoptosis.
Conclusion: Butin had the potential as a pharmaceutical candidate for treating skin damage caused by PM _2.5 and UVB exposure.
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