PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee.

Here, we expound on the view that Xist RNA directly controls Polycomb repressive complex 2 (PRC2) recruitment, off-loading to chromatin, catalytic activity, and eviction from chromatin. RNA-PRC2 interactions also control RNA polymerase II transcription pausing. Dynamic RNA folding determines PRC2 activity. Disparate studies and interpretations abound but can be reconciled.
Competing Interests: Declaration of interests J.T.L. is an advisor to Skyhawk Therapeutics, a co-founder of Fulcrum Therapeutics, and a Non-Executive Director of the GSK. To the author’s knowledge, none of these entities work in the subject area covered by this commentary.
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