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Advances in Factors Affecting ALDH2 Activity and its Mechanisms.
Advances in Factors Affecting ALDH2 Activity and its Mechanisms.
- Source :
-
Cardiovascular toxicology [Cardiovasc Toxicol] 2024 Dec; Vol. 24 (12), pp. 1428-1438. Date of Electronic Publication: 2024 Oct 04. - Publication Year :
- 2024
-
Abstract
- Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme primarily involved in the detoxification of alcohol-derived aldehyde and endogenous toxic aldehydes. It exhibits widespread expression across various organs and exerts a broad and significant impact on diverse acute cardiovascular diseases, including acute coronary syndrome, acute aortic dissection, hypoxic pulmonary hypertension, and heart failure. The ALDH2 rs671 variant represents the most prevalent genetic variant in East Asian populations, with carriage rates ranging from 30 to 50% among the Chinese population. Given its widespread presence in the body, the wide range of diseases it affects, and its high rate of variation, it can serve as a crucial tool for the precise prevention and treatment of acute cardiovascular diseases, while offering individualized medication guidance. This review aims to provide a comprehensive overview of the latest advancements in factors affecting ALDH2 activity, encompassing post-transcriptional modifications, modulators of ALDH2, and relevant clinical drugs.<br />Competing Interests: Declarations Competing Interests The authors declare no competing interests.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Humans
Animals
Cardiovascular Diseases enzymology
Cardiovascular Diseases genetics
Cardiovascular Diseases metabolism
Phenotype
Protein Processing, Post-Translational
Acetaldehyde Dehydrogenase Inhibitors
Pharmacogenomic Variants
Aldehyde Dehydrogenase, Mitochondrial genetics
Aldehyde Dehydrogenase, Mitochondrial metabolism
Genetic Predisposition to Disease
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0259
- Volume :
- 24
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cardiovascular toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 39365551
- Full Text :
- https://doi.org/10.1007/s12012-024-09923-9