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Accessing the vasculature in cancer: revising an old hallmark.
- Source :
-
Trends in cancer [Trends Cancer] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- The classic cancer hallmark, inducing angiogenesis, was born out of the long-held notion that tumours could grow only if new vessels were formed. The attempts, based on this premise, to therapeutically restrain angiogenesis in hopes of controlling tumour growth have been less effective than expected. This is partly because primary and metastatic tumours can grow without angiogenesis. The discovery of nonangiogenic cancers and the mechanisms they use to exploit normal vessels, called 'vessel co-option,' has opened a new field in cancer biology. Consequently, the cancer hallmark, 'inducing angiogenesis,' has been modified to 'inducing or accessing vasculature.'<br />Competing Interests: Declaration of interests The authors have no competing interests to declare.<br /> (Copyright © 2024. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 2405-8025
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 39358088
- Full Text :
- https://doi.org/10.1016/j.trecan.2024.08.003